The human genome contains 39 myosin genes, divided up into 12 different classes. The structure, cellular function and biochemical properties of many of these isoforms remain poorly characterized and there is still some controversy as to whether some myosin isoforms are monomers or dimers. Myosin isoforms 6 and 10 contain a stable single α-helical (SAH) domain, situated just after the canonical lever. The SAH domain is stiff enough to be able to lengthen the lever allowing the myosin to take a larger step. In addition, atomic force microscopy and atomistic simulations show that SAH domains unfold at relatively low forces and have a high propensity to refold. These properties are likely to be important for protein function, enabling motors to carry cargo in dense actin networks, and other proteins to remain attached to binding partners in the crowded cell.
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February 2015
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Conference Article|
January 26 2015
Myosin tails and single α-helical domains
Matthew Batchelor;
Matthew Batchelor
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Marcin Wolny;
Marcin Wolny
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Lorna Dougan;
Lorna Dougan
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Emanuele Paci;
Emanuele Paci
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Peter J. Knight;
Peter J. Knight
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Michelle Peckham
Michelle Peckham
1
*Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
1To whom correspondence should be addressed (emailm.peckham@leeds.ac.uk).
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Publisher: Portland Press Ltd
Received:
November 14 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (1): 58–63.
Article history
Received:
November 14 2014
Citation
Matthew Batchelor, Marcin Wolny, Lorna Dougan, Emanuele Paci, Peter J. Knight, Michelle Peckham; Myosin tails and single α-helical domains. Biochem Soc Trans 1 February 2015; 43 (1): 58–63. doi: https://doi.org/10.1042/BST20140302
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