The cytoplasmic dynein complex is the major minus-end-directed microtubule motor. Although its directionality is evolutionary well conserved, differences exist among cytoplasmic dyneins from different species in their stepping behaviour, maximum velocity and force production. Recent experiments also suggest differences in processivity regulation. In the present article, we give an overview of dynein's motile properties, with a special emphasis on processivity and its regulation. Furthermore, we summarize recent findings of different pathways for microtubule plus-end loading of dynein. The present review highlights how distinct functions in different cell types or organisms appear to require different mechanochemical dynein properties and localization pathways.
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February 2015
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Conference Article|
January 26 2015
Regulation of processive motion and microtubule localization of cytoplasmic dynein
Rupam Jha;
Rupam Jha
*London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, U.K.
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Thomas Surrey
Thomas Surrey
1
*London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, U.K.
1To whom correspondence should be addressed (emailThomas.surrey@cancer.org.uk).
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Publisher: Portland Press Ltd
Received:
September 22 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (1): 48–57.
Article history
Received:
September 22 2014
Citation
Rupam Jha, Thomas Surrey; Regulation of processive motion and microtubule localization of cytoplasmic dynein. Biochem Soc Trans 1 February 2015; 43 (1): 48–57. doi: https://doi.org/10.1042/BST20140252
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