Cytokinesis is an intricate process that requires an intimate interplay between actomyosin ring constriction and plasma membrane remodelling at the cleavage furrow. However, the molecular mechanisms involved in coupling the cytoskeleton dynamics with vesicle trafficking during cytokinesis are poorly understood. The highly conserved Golgi phosphoprotein 3 (GOLPH3), functions as a phosphatidylinositol 4-phosphate (PI4P) effector at the Golgi. Recent studies have suggested that GOLPH3 is up-regulated in several cancers and is associated with poor prognosis and more aggressive tumours. In Drosophila melanogaster, GOLPH3 localizes at the cleavage furrow of dividing cells, is required for successful cytokinesis and acts as a key molecule in coupling phosphoinositide (PI) signalling with actomyosin ring dynamics. Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy.
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February 2015
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Conference Article|
January 26 2015
The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis
Stefano Sechi;
Stefano Sechi
*Istituto di Biologia e Patologia molecolari del CNR, Università Sapienza di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
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Anna Frappaolo;
Anna Frappaolo
*Istituto di Biologia e Patologia molecolari del CNR, Università Sapienza di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
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Giorgio Belloni;
Giorgio Belloni
†Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
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Maria Grazia Giansanti
Maria Grazia Giansanti
1
*Istituto di Biologia e Patologia molecolari del CNR, Università Sapienza di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
1To whom correspondence should be addressed (email mariagrazia.giansanti@uniroma1.it).
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Publisher: Portland Press Ltd
Received:
September 29 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (1): 117–121.
Article history
Received:
September 29 2014
Citation
Stefano Sechi, Anna Frappaolo, Giorgio Belloni, Maria Grazia Giansanti; The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans 1 February 2015; 43 (1): 117–121. doi: https://doi.org/10.1042/BST20140264
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