Mitochondria are the powerhouse of cells as they produce the bulk of ATP which is consumed by the cell. They form a highly interconnected network that is governed by fission and fusion processes. In addition, mitochondria and the endoplasmic reticulum (ER) are found in close proximity to each other and it is thought that they maintain contact sites to exchange molecules. The regulation and the function of these contact sites need to be further explored. The small GTPase Arf1 (ADP-ribosylation factor 1), which is best known for its essential role in the generation of coatomer protein I (COPI)-coated vesicles at the Golgi complex appears to be also essential for the dynamics and maintenance of mitochondrial function, presumably at ER–mitochondrial contact sites.
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February 2015
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Conference Article|
January 26 2015
A small GTPase involved in mitochondrial morphology and function
Anne Spang
Anne Spang
1
*Growth & Development, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
1To whom correspondence should be addressed (emailanne.spang@unibas.ch).
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Publisher: Portland Press Ltd
Received:
October 21 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (1): 108–110.
Article history
Received:
October 21 2014
Citation
Anne Spang; A small GTPase involved in mitochondrial morphology and function. Biochem Soc Trans 1 February 2015; 43 (1): 108–110. doi: https://doi.org/10.1042/BST20140284
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