Collagens are secreted into the extracellular space where they assemble into a large complex protein network to form basement membrane and extracellular matrix. Collagens are therefore essential for cell attachment, tissue organization and the overall survival of all multicellular organisms. Collagens are synthesized in the endoplasmic reticulum (ER) but they are too big to fit into a conventional coat protein complex II (COPII) transport carrier of 60–90 nm average diameter. How are these molecules exported from the ER and then transported along the secretory pathway? We describe here the involvement of special packing machinery composed of hetero oligomers of transport and Golgi organization 1 (TANGO1) and cutaneous T-cell lymphoma-associated antigen 5 (cTAGE5) in the export of procollagen VII from the ER.
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February 2015
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Conference Article|
January 26 2015
Procollagen export from the endoplasmic reticulum
Vivek Malhotra;
Vivek Malhotra
1
*Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain
†Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10, 08002 Barcelona, Spain
‡Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain
1To whom correspondence should be addressed (emailvivek.malhotra@crg.eu).
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Patrik Erlmann;
Patrik Erlmann
*Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain
†Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10, 08002 Barcelona, Spain
‡Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain
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Cristina Nogueira
Cristina Nogueira
*Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain
†Universitat Pompeu Fabra (UPF), Plaça de la Mercè 10, 08002 Barcelona, Spain
‡Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain
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Publisher: Portland Press Ltd
Received:
October 23 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem Soc Trans (2015) 43 (1): 104–107.
Article history
Received:
October 23 2014
Citation
Vivek Malhotra, Patrik Erlmann, Cristina Nogueira; Procollagen export from the endoplasmic reticulum. Biochem Soc Trans 1 February 2015; 43 (1): 104–107. doi: https://doi.org/10.1042/BST20140286
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