Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology alignment results confirming ELTD1 to be a hybrid comprising motifs shared with individual members in both adhesion GPCR subfamilies 1 and 2. Finally, we discuss why tumour endothelial ELTD1 expression may confer a good prognosis yet still represent a therapeutic target.
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December 2014
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Conference Article|
November 17 2014
A review of ELTD1, a pro-angiogenic adhesion GPCR
David M. Favara;
David M. Favara
1
*Department of Oncology, University of Oxford, Oxford, U.K.
†Balliol College, University of Oxford, Oxford, U.K.
1To whom correspondence should be addressed (emaildavid.favara@balliol.ox.ac.uk).
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Alison H. Banham;
Alison H. Banham
‡NDCLS-Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
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Adrian L. Harris
Adrian L. Harris
*Department of Oncology, University of Oxford, Oxford, U.K.
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Publisher: Portland Press Ltd
Received:
August 06 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1658–1664.
Article history
Received:
August 06 2014
Citation
David M. Favara, Alison H. Banham, Adrian L. Harris; A review of ELTD1, a pro-angiogenic adhesion GPCR. Biochem Soc Trans 1 December 2014; 42 (6): 1658–1664. doi: https://doi.org/10.1042/BST20140216
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