Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia, such as neovascular eye disease and cancer. Neuropilin 1 (NRP1) is a transmembrane protein that serves as a receptor for the VEGF165 isoform of the vascular endothelial growth factor (VEGF) to enhance cell migration during angiogenesis via VEGF receptor 2 (VEGFR2), and it is also essential for VEGF-induced vascular permeability and arteriogenesis. In addition, NRP1 activation affects angiogenesis independently of VEGF signalling by activating the intracellular kinase ABL1. NRP1 also acts as a receptor for the class 3 semaphorin (SEMA3A) to regulate vessel maturation during tumour angiogenesis and vascular permeability in eye disease. In the present paper, we review current knowledge of NRP1 regulation during angiogenesis and vascular pathology.
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December 2014
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Conference Article|
November 17 2014
Neuropilin regulation of angiogenesis
Anastasia Lampropoulou;
Anastasia Lampropoulou
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
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Christiana Ruhrberg
Christiana Ruhrberg
1
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
1To whom correspondence should be addressed (emailc.ruhrberg@ucl.ac.uk).
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Publisher: Portland Press Ltd
Received:
September 15 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1623–1628.
Article history
Received:
September 15 2014
Citation
Anastasia Lampropoulou, Christiana Ruhrberg; Neuropilin regulation of angiogenesis. Biochem Soc Trans 1 December 2014; 42 (6): 1623–1628. doi: https://doi.org/10.1042/BST20140244
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