Protein kinase Cθ (PKCθ) is a member of the novel calcium-independent PKC family, with a relatively selective tissue distribution. Most studies have focused on its unique role in T-lymphocyte activation and suggest that inhibition of PKCθ could represent a novel therapeutic approach in the treatment of chronic inflammation, autoimmunity and allograft rejection. However, considering that PKCθ is also expressed in other cell types, including skeletal muscle cells, it is important to understand its function in different tissues before proposing it as a molecular target for the treatment of immune-mediated diseases. A number of studies have highlighted the role of PKCθ in mediating several intracellular pathways, regulating muscle cell development, homoeostasis and remodelling, although a comprehensive picture is still lacking. Moreover, we recently showed that lack of PKCθ in a mouse model of Duchenne muscular dystrophy (DMD) ameliorates the progression of the disease. In the present article, we review new developments in our understanding of the involvement of PKCθ in intracellular mechanisms regulating skeletal muscle development, growth and maintenance under physiological conditions and recent advances showing a hitherto unrecognized role of PKCθ in promoting muscular dystrophy.
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December 2014
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Conference Article|
November 17 2014
Targeting PKCθ in skeletal muscle and muscle diseases: good or bad?
Valeria Marrocco;
Valeria Marrocco
1
*DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy
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Piera Fiore;
Piera Fiore
1
*DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy
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Luca Madaro;
Luca Madaro
†IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano, 64, 00143 Rome, Italy
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Annunziata Crupi;
Annunziata Crupi
*DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy
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Biliana Lozanoska-Ochser;
Biliana Lozanoska-Ochser
1
*DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy
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Marina Bouché
*DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 14, 00161 Rome, Italy
2To whom correspondence should be addressed (emailmarina.bouche@uniroma1.it).
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Publisher: Portland Press Ltd
Received:
August 04 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1550–1555.
Article history
Received:
August 04 2014
Citation
Valeria Marrocco, Piera Fiore, Luca Madaro, Annunziata Crupi, Biliana Lozanoska-Ochser, Marina Bouché; Targeting PKCθ in skeletal muscle and muscle diseases: good or bad?. Biochem Soc Trans 1 December 2014; 42 (6): 1550–1555. doi: https://doi.org/10.1042/BST20140207
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