In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many questions remain on the specific functions regulated by these isoforms and their mechanism of activation and action. In the present review, we discuss results from recent studies that have provided some answers to these questions.
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Conference Article| September 18 2014
New insight into the intracellular roles of class II phosphoinositide 3-kinases
Tania Maffucci 1
*Inositide Signalling Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.
1To whom correspondence should be addressed (firstname.lastname@example.org).
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Tania Maffucci, Marco Falasca; New insight into the intracellular roles of class II phosphoinositide 3-kinases. Biochem Soc Trans 1 October 2014; 42 (5): 1378–1382. doi: https://doi.org/10.1042/BST20140140
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