Chemical intervention tools have been beneficial to many investigations elucidating signalling networks and interactions. The present review summarizes the current status of chemical tools to probe phosphoinositide metabolism and signalling. In particular, phosphoinositide-targeting tools are compared with protein-targeting tools with respect to their unique advantages and possible applications.

Keywords:
chemical intervention tool, inhibitor, mimetic, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), phosphatidylinositol, phosphoinositide 3-kinase (PI3K)
© The Authors Journal compilation © 2014 Biochemical Society
2014
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