There is growing interest in the family of 2-OG (2-oxoglutarate)-dependent dioxygenase enzymes that catalyse the hydroxylation of a wide range of organic targets. Members of this family that regulate the cell's hypoxic response and epigenetic processes, particularly the demethylation of histones and DNA, have been identified in mammalian cells. The dependence of these enzymes on molecular oxygen and 2-OG as obligatory substrates, together with their need for iron and ascorbate as cofactors, has implications for their role as metabolic sensors. The oxygen-sensing property is utilized by the hydroxylases that regulate hypoxia-inducible factor and this has been well characterized, particularly with respect to tumour biology. However, the potential for metabolic sensing more generally is also of interest, and future research will expand our understanding of the effect of mitochondrial viability and nutrient (iron and ascorbate) supply on 2-OG-dependent dioxygenase activity.
Skip Nav Destination
Article navigation
August 2014
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
August 11 2014
Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer
Margreet C.M. Vissers;
Margreet C.M. Vissers
1
*Centre for Free Radical Research, Pathology Department, University of Otago, Christchurch, P.O. Box 4345, Christchurch, New Zealand
1To whom correspondence should be addressed (emailmargreet.vissers@otago.ac.nz).
Search for other works by this author on:
Caroline Kuiper;
Caroline Kuiper
*Centre for Free Radical Research, Pathology Department, University of Otago, Christchurch, P.O. Box 4345, Christchurch, New Zealand
Search for other works by this author on:
Gabi U. Dachs
Gabi U. Dachs
†McKenzie Cancer Research Group, Pathology Department, University of Otago, Christchurch, P.O. Box 4345, Christchurch, New Zealand
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 29 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 945–951.
Article history
Received:
April 29 2014
Citation
Margreet C.M. Vissers, Caroline Kuiper, Gabi U. Dachs; Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer. Biochem Soc Trans 1 August 2014; 42 (4): 945–951. doi: https://doi.org/10.1042/BST20140118
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.