The localization of mRNA forms a key facet of the post-transcriptional control of gene expression and recent evidence suggests that it may be considerably more widespread than previously anticipated. For example, defined mRNA-containing granules can be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces cerevisiae, examining connections between organellar mRNA localization and the response to stress. We also review recent data suggesting that even where there is a global relocalization of mRNA, the specificity and kinetics of this process can be regulated.
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Conference Article|
August 11 2014
Yeast mRNA localization: protein asymmetry, organelle localization and response to stress
Mariavittoria Pizzinga;
Mariavittoria Pizzinga
*Faculty of Life Sciences, Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
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Mark P. Ashe
Mark P. Ashe
1
*Faculty of Life Sciences, Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (emailmark.p.ashe@manchester.ac.uk).
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Publisher: Portland Press Ltd
Received:
April 02 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1256–1260.
Article history
Received:
April 02 2014
Citation
Mariavittoria Pizzinga, Mark P. Ashe; Yeast mRNA localization: protein asymmetry, organelle localization and response to stress. Biochem Soc Trans 1 August 2014; 42 (4): 1256–1260. doi: https://doi.org/10.1042/BST20140086
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