With the advances in deep-sequencing techniques over the last decade, the study of alternative cleavage and polyadenylation (APA) has shifted from individual gene to whole transcriptome analysis. Findings from such global studies have elevated APA to its currently accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown. The present review aims to summarize the experimental evidence that supports a physiological role of APA and highlights some of the shortcomings that need addressing to substantiate the widely proposed claim that APA is a key player in global gene regulation.
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August 2014
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Conference Article|
August 11 2014
Alternative polyadenylation: less than meets the eye?
Jonathan Neve;
Jonathan Neve
1
*Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
1To whom correspondence should be addressed (emailjonathan.neve@pmb.ox.ac.uk).
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André Furger
André Furger
*Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
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Publisher: Portland Press Ltd
Received:
March 05 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1190–1195.
Article history
Received:
March 05 2014
Citation
Jonathan Neve, André Furger; Alternative polyadenylation: less than meets the eye?. Biochem Soc Trans 1 August 2014; 42 (4): 1190–1195. doi: https://doi.org/10.1042/BST20140054
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