Endo-siRNAs (endogenous small-interfering RNAs) have recently emerged as versatile regulators of gene expression. They derive from double-stranded intrinsic transcripts and are processed by Dicer and associate with Argonaute proteins. In Caenorhabditis elegans, endo-siRNAs are known as 22G and 26G RNAs and are involved in genome protection and gene regulation. Drosophila melanogaster endo-siRNAs are produced with the help of specific Dicer and Argonaute isoforms and play an essential role in transposon control and the protection from viral infections. Biological functions of endo-siRNAs in vertebrates include repression of transposable elements and chromatin organization, as well as gene regulation at the transcriptional and post-transcriptional levels.
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Conference Article|
August 11 2014
Endogenous siRNAs: regulators of internal affairs
Monica J. Piatek;
Monica J. Piatek
*RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, U.K.
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Andreas Werner
Andreas Werner
1
*RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, U.K.
1To whom correspondence should be addressed (emailandreas.werner@ncl.ac.uk).
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Publisher: Portland Press Ltd
Received:
March 28 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1174–1179.
Article history
Received:
March 28 2014
Citation
Monica J. Piatek, Andreas Werner; Endogenous siRNAs: regulators of internal affairs. Biochem Soc Trans 1 August 2014; 42 (4): 1174–1179. doi: https://doi.org/10.1042/BST20140068
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