Superoxide and its derived ROS (reactive oxygen species) have been considered for a long time to be generated as toxic by-products of metabolic events. Although ROS generated in low amounts are able to act as signalling molecules, ROS appear to also play a major role in aging and in the pathogenesis of diseases such as inflammation, diabetes and cancer. Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may be critical for tissue homoeostasis. However, the underlying regulatory mechanisms appear to be multiple and this article summarizes current aspects by which MnSOD can regulate carcinogenesis under various conditions.
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August 2014
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Conference Article|
August 11 2014
Manganese superoxide dismutase in carcinogenesis: friend or foe?
Anja Konzack;
Anja Konzack
*Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Aapistie 7B, Oulu, Finland
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Thomas Kietzmann
Thomas Kietzmann
1
*Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Aapistie 7B, Oulu, Finland
1To whom correspondence should be addressed (emailtkietzm@gwdg.de).
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Publisher: Portland Press Ltd
Received:
April 01 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Article history
Received:
April 01 2014
Citation
Anja Konzack, Thomas Kietzmann; Manganese superoxide dismutase in carcinogenesis: friend or foe?. Biochem Soc Trans 1 August 2014; 42 (4): 1012–1016. doi: https://doi.org/10.1042/BST20140076
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