Glo1 (glyxoalase I) is a cytosolic protein expressed in all mammalian cells. Its physiological function is the detoxification of MG (methylglyoxal), which is a potent precursor of AGEs (advanced glycation end-products). Although the impact of AGEs on different forms of vascular diseases has been intensively investigated, the evidence for the involvement of Glo1 and MG is still scarce. Recently, several studies have provided significant evidence for Glo1 having a protective effect on microvascular complications in diabetic patients, such as retinopathy and nephropathy. Regarding macrovascular complications, especially atherosclerotic lesions, the impact of Glo1 is even less clear. In the present article, we review the latest findings regarding the role of Glo1 and MG in vascular biology and the pathophysiology of micro- and macro-vascular disease.
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April 2014
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Conference Article|
March 20 2014
Glyoxalase I (Glo1) and its metabolites in vascular disease
Markus Wortmann;
Markus Wortmann
1
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany
1To whom correspondence should be addressed (emailmarkus.wortmann@med.uni-heidelberg.de).
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Andreas S. Peters;
Andreas S. Peters
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany
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Maani Hakimi;
Maani Hakimi
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany
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Dittmar Böckler;
Dittmar Böckler
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany
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Susanne Dihlmann
Susanne Dihlmann
*Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany
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Publisher: Portland Press Ltd
Received:
January 06 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (2): 528–533.
Article history
Received:
January 06 2014
Citation
Markus Wortmann, Andreas S. Peters, Maani Hakimi, Dittmar Böckler, Susanne Dihlmann; Glyoxalase I (Glo1) and its metabolites in vascular disease. Biochem Soc Trans 1 April 2014; 42 (2): 528–533. doi: https://doi.org/10.1042/BST20140003
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