Patients suffering from DN (diabetic neuropathy) suffer from the coexistence of positive (i.e. pain, hypersensitivity, tingling, cramps, cold feet, etc.) and negative (i.e. loss of sensory perception, delayed wound healing, etc.) symptoms. Elevated blood glucose alone cannot explain the development and progression of DN. Recently it has been shown that the endogenous reactive metabolite MG (methylglyoxal), elevated as a consequence of reduced Glo1 (glyoxalase I), can contribute to the gain of function via post-translational modification of neuronal ion channels involved in chemosensing and action potential generation in nociceptive nerve endings. The effects of dicarbonyls on the neuronal compartment provides a unifying mechanism for the development of DN. Targeting the accumulation and effects of MG may therefore provide new, more effective, therapeutic approaches for the treatment of DN.
Skip Nav Destination
Article navigation
April 2014
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
March 20 2014
Reactive metabolites as a cause of late diabetic complications
Thomas Fleming;
Thomas Fleming
1
*Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, 69120 Heidelberg, Germany
1To whom correspondence should be addressed (emailThomas.Fleming@med.uni-heidelberg.de).
Search for other works by this author on:
Peter P. Nawroth
Peter P. Nawroth
*Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, 69120 Heidelberg, Germany
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 04 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (2): 439–442.
Article history
Received:
December 04 2013
Citation
Thomas Fleming, Peter P. Nawroth; Reactive metabolites as a cause of late diabetic complications. Biochem Soc Trans 1 April 2014; 42 (2): 439–442. doi: https://doi.org/10.1042/BST20130265
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.