Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful endogenous regulator of blood platelet activation. PKA (protein kinase A), the foremost effector of cAMP signalling in platelets, phosphorylates a number of proteins that are thought to modulate multiple aspects of platelet activation. In the present mini-review, we outline our current understanding of cAMP-mediated platelet inhibition and discuss some of the issues that require clarification.
Skip Nav Destination
Conference Article| March 20 2014
The control of blood platelets by cAMP signalling
Khalid M. Naseem
Khalid M. Naseem 1
*Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Cottingham Road, Hull HU6 7RX, U.K.
1To whom correspondence should be addressed (firstname.lastname@example.org).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received: December 19 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
Zaher Raslan, Khalid M. Naseem; The control of blood platelets by cAMP signalling. Biochem Soc Trans 1 April 2014; 42 (2): 289–294. doi: https://doi.org/10.1042/BST20130278
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article