Dozens of papers have been written about the relationship between codon bias, transcript features and gene translation. Even though answering these questions may sound straightforward, apparently many of these studies seem to contradict each other. In the present article, I provide four major non-mutually exclusive explanations related to this issue: (i) there are dozens of related relevant variables with unknown causal relationships; (ii) various biases in the relevant experimental data; (iii) drawing conclusions from specific examples; and (iv) challenges in experimentally modifying one biological variable without affecting the system via multiple biological feedback mechanisms. Specifically, some of the contradictions can be settled when considering these four points and/or via a multidisciplinary approach. The discussion reported in the present article is also relevant to many other biological/medical questions/fields.
Skip Nav Destination
Article navigation
February 2014
- Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
January 23 2014
Challenges and obstacles related to solving the codon bias riddles
Tamir Tuller
Tamir Tuller
1
*Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
†The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel
1emailtamirtul@post.tau.ac.il
Search for other works by this author on:
Biochem Soc Trans (2014) 42 (1): 155–159.
Article history
Received:
June 12 2013
Citation
Tamir Tuller; Challenges and obstacles related to solving the codon bias riddles. Biochem Soc Trans 1 February 2014; 42 (1): 155–159. doi: https://doi.org/10.1042/BST20130095
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.