The spindle assembly checkpoint is a conserved mitotic signalling pathway that ensures the equal segregation of chromosomes to daughter cells. Despite intensive work in many model organisms, key features of this safety mechanism remain unexplained. In the present review, I briefly summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway.

Keywords:
anaphase-promoting complex (APC), mitosis, mitotic checkpoint, signalling pathway, spindle assembly checkpoint
© The Authors Journal compilation © 2013 Biochemical Society
2013
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