The human nervous system expresses approximately 70% of all miRNAs (microRNAs). Changing levels of certain ubiquitous and brain-specific miRNAs shape the development and function of the nervous system. It is becoming clear that misexpression of some miRNAs can contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system.

Keywords:
microRNA (miRNA), microRNA biogenesis, nervous system, neuropathogenesis, synaptic plasticity
© The Authors Journal compilation © 2013 Biochemical Society
2013
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