Pseudokinases are a class of kinases which are structurally designated as lacking kinase activity. Despite the lack of kinase domain sequence conservation, there is increasing evidence that a number of pseudokinases retain kinase activity and/or have critical cellular functions, casting aside previous notions that pseudokinases simply exist as redundant kinases. Moreover, a number of recent studies have implicated pseudokinases as critical components in cancer formation and progression. The present review discusses the interactions and potential functions that nuclear receptor-binding protein 1, a pseudokinase recently described to have a tumour-suppressive role in cancer, may play in cellular homoeostasis and protein regulation. The recent findings highlighted in the present review emphasize the requirement to fully determine the function of pseudokinases in vitro and in vivo, the understanding of which may ultimately uncover new directions for drug discovery.
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August 2013
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Conference Article|
July 18 2013
Nuclear receptor-binding protein 1: a novel tumour suppressor and pseudokinase
Jason S. Kerr;
Jason S. Kerr
*School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
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Catherine H. Wilson
Catherine H. Wilson
1
†Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K.
1To whom correspondence should be addressed (emailchw39@cam.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 01 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (4): 1055–1060.
Article history
Received:
May 01 2013
Citation
Jason S. Kerr, Catherine H. Wilson; Nuclear receptor-binding protein 1: a novel tumour suppressor and pseudokinase. Biochem Soc Trans 1 August 2013; 41 (4): 1055–1060. doi: https://doi.org/10.1042/BST20130069
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