Structural studies of members of the CDK (cyclin-dependent protein kinase) family have made a significant contribution to our understanding of the regulation of protein kinases. The structure of monomeric unphosphorylated CDK2 was the first of an inactive protein kinase to be determined and, since then, structures of other members of the CDK family, alone, in complex with regulatory proteins and in differing phosphorylation states, have enhanced our understanding of the molecular mechanisms regulating protein kinase activity. Recently, our knowledge of the structural biology of the CDK family has been extended by determination of structures for members of the transcriptional CDK and CDK-like kinase branches of the extended family. We include these recent structures in the present review and consider them in the light of current models for CDK activation and regulation.
Skip Nav Destination
Article navigation
August 2013
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 18 2013
Structural characterization of the cyclin-dependent protein kinase family
Jane A. Endicott;
Jane A. Endicott
1
1Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
1To whom correspondence should be addressed (emailjane.endicott@ncl.ac.uk).
Search for other works by this author on:
Martin E.M. Noble
Martin E.M. Noble
1Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 03 2013
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (4): 1008–1016.
Article history
Received:
June 03 2013
Citation
Jane A. Endicott, Martin E.M. Noble; Structural characterization of the cyclin-dependent protein kinase family. Biochem Soc Trans 1 August 2013; 41 (4): 1008–1016. doi: https://doi.org/10.1042/BST20130097
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.