DNA supercoiling and NAPs (nucleoid-associated proteins) contribute to the regulation of transcription of many bacterial genes. The horizontally acquired SPI (Salmonella pathogenicity island) genes respond positively to DNA relaxation, they are activated and repressed by the Fis (factor for inversion stimulation) and H-NS (histone-like nucleoid-structuring) NAPs respectively, and are positively controlled by the OmpR global regulatory protein. The ompR gene is autoregulated and responds positively to DNA relaxation. Binding of the Fis and OmpR proteins to their targets in DNA is differentially sensitive to its topological state, whereas H-NS binds regardless of the topological state of the DNA. These data illustrate the overlapping and complex nature of NAP and DNA topological contributions to transcription control in bacteria.
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Conference Article|
March 21 2013
Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription
Charles J. Dorman
Charles J. Dorman
1
1Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
1emailcjdorman@tcd.ie
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Publisher: Portland Press Ltd
Received:
August 29 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem Soc Trans (2013) 41 (2): 542–547.
Article history
Received:
August 29 2012
Citation
Charles J. Dorman; Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription. Biochem Soc Trans 1 April 2013; 41 (2): 542–547. doi: https://doi.org/10.1042/BST20120222
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