The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic α-subunit and regulatory β- and FXYD subunits. All three subunits may become palmitoylated, although the functional outcome of these palmitoylation events is incompletely characterized to date. Interestingly, both β- and FXYD subunits may be palmitoylated or glutathionylated at the same cysteine residues. These competing chemically distinct post-translational modifications may mediate functionally different effects on the cardiac pump. In the present article, we review the cellular events that control the balance between these modifications, and discuss the likely functional effects of pump subunit palmitoylation.
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February 2013
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Conference Article|
January 29 2013
Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits
Jacqueline Howie;
Jacqueline Howie
*Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, U.K.
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Lindsay B. Tulloch;
Lindsay B. Tulloch
*Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, U.K.
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Michael J. Shattock;
Michael J. Shattock
†Cardiovascular Division, King's College London, London SE1 7EH, U.K.
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William Fuller
William Fuller
1
*Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, U.K.
1To whom correspondence should be addressed (emailw.fuller@dundee.ac.uk).
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Biochem Soc Trans (2013) 41 (1): 95–100.
Article history
Received:
October 17 2012
Citation
Jacqueline Howie, Lindsay B. Tulloch, Michael J. Shattock, William Fuller; Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochem Soc Trans 1 February 2013; 41 (1): 95–100. doi: https://doi.org/10.1042/BST20120269
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