Microcins are gene-encoded antibacterial peptides of low molecular mass (<10 kDa), produced by Enterobactericeae. They are produced and secreted under conditions of limited essential nutrients and are active against related species. Bacterial strains under starvation conditions can produce and release microcins that can kill microcin-sensitive cells and therefore have more nutrients for survival. The outer-membrane protein OmpF and FhuA TonB-dependent pathways facilitate the internalization of the MccB17 and MccJ25 microcins into the target cell respectively. The inner-membrane protein SbmA transports the microcins through the inner membrane to the cytoplasmic face. Inside the cell, MccB17 targets DNA gyrase, whereas MccJ25 inhibits the bacterial RNA polymerase.
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December 2012
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Conference Article|
November 21 2012
The role of bacterial membrane proteins in the internalization of microcin MccJ25 and MccB17
Indran Mathavan;
Indran Mathavan
1Division of Molecular Biosciences, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, U.K., Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Oxfordshire OX11 0DE, U.K., and Research Complex at Harwell, Harwell, Didcot, Oxfordshire OX11 0FA, U.K.
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Konstantinos Beis
Konstantinos Beis
1
1Division of Molecular Biosciences, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, U.K., Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Oxfordshire OX11 0DE, U.K., and Research Complex at Harwell, Harwell, Didcot, Oxfordshire OX11 0FA, U.K.
1To whom correspondence should be addressed (emailkbeis@imperial.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 27 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1539–1543.
Article history
Received:
July 27 2012
Citation
Indran Mathavan, Konstantinos Beis; The role of bacterial membrane proteins in the internalization of microcin MccJ25 and MccB17. Biochem Soc Trans 1 December 2012; 40 (6): 1539–1543. doi: https://doi.org/10.1042/BST20120176
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