Whereas most of what we know today about the Ras-related small GTPases of the Rab family stems from observations made on Golgi complex, endosome and plasma membrane trafficking, a subset of Rabs localizes in part or predominantly to the ER (endoplasmic reticulum). Here, Rabs such as Rab1, Rab2, Rab6 and Rab33 can regulate the anterograde and retrograde trafficking of vesicles between the Golgi complex, the ERGIC (ER–Golgi intermediate compartment) and the ER itself. However, among the ER-associated Rabs, some Rabs appear to perform roles not directly related to trafficking: these Rabs (e.g. Rab32 or Rab24) could aid proteins of the atlastin and reticulon families in determining the extent and direction of ER tubulation. In so doing, these Rabs regulate not only ER contacts with other organelles such as mitochondria, but also the formation of autophagosomes.
Skip Nav Destination
Article navigation
December 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2012
Rab proteins of the endoplasmic reticulum: functions and interactors
Carolina Ortiz Sandoval;
Carolina Ortiz Sandoval
1Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
Search for other works by this author on:
Thomas Simmen
Thomas Simmen
1
1Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
1To whom correspondence should be addressed (emailThomas.Simmen@ualberta.ca).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 27 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1426–1432.
Article history
Received:
June 27 2012
Citation
Carolina Ortiz Sandoval, Thomas Simmen; Rab proteins of the endoplasmic reticulum: functions and interactors. Biochem Soc Trans 1 December 2012; 40 (6): 1426–1432. doi: https://doi.org/10.1042/BST20120158
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.