As intracellular pathogens, enveloped viruses must usurp the host cell machinery for many stages of the viral life cycle in order to produce a new generation of infectious virions. In one of the less understood steps of viral assembly, viral components including the transmembrane glycoproteins, structural proteins and the viral genome must be targeted to the site of viral budding, where they assemble and are incorporated into a newly formed virion that gains a lipid envelope from a cellular membrane. Recent work has revealed that the cellular recycling endosome pathway, in particular Rab11, plays an important role in the assembly of negative-strand RNA viruses such as respiratory syncytial virus, influenza A virus, Andes virus and Sendai virus. The present mini-review discusses this emerging field and explores the potential roles of the Rab11 pathway in the trafficking, assembly and budding steps of these viruses.
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December 2012
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Conference Article|
November 21 2012
Role of the Rab11 pathway in negative-strand virus assembly
Emily A. Bruce;
Emily A. Bruce
1
*Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, U.S.A.
1To whom correspondence should be addressed (emailembruce@gmail.com).
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Amanda Stuart;
Amanda Stuart
†Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.
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Mary W. McCaffrey;
Mary W. McCaffrey
‡Molecular Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
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Paul Digard
Paul Digard
§Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, U.K.
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Publisher: Portland Press Ltd
Received:
July 10 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1409–1415.
Article history
Received:
July 10 2012
Citation
Emily A. Bruce, Amanda Stuart, Mary W. McCaffrey, Paul Digard; Role of the Rab11 pathway in negative-strand virus assembly. Biochem Soc Trans 1 December 2012; 40 (6): 1409–1415. doi: https://doi.org/10.1042/BST20120166
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