Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function, bioenergetics, proliferation, motility, invasion, metastasis, apoptosis and autophagy. The Rab GTPases, along with their effectors, are critical regulators of this endocytic machinery and can have a huge impact on the cellular itinerary of growth and metabolism. Rab25 is an epithelial-cell-specific member of the Rab GTPase superfamily, sharing close homology with Rab11a, the endosomal recycling Rab GTPase. RAB25 has been implicated in various cancers, with reports presenting it as both an oncogene and a tumour-suppressor gene. At the cellular level, Rab25 was shown to contribute to invasiveness of cancer cells by regulating integrin trafficking. Recently, our laboratory uncovered a critical role for Rab25 in cellular energetics. Assimilating all of the existing evidence, in the present review, we give an updated overview of the complex and often context-dependent role of Rab25 in cancer.
Skip Nav Destination
Article navigation
December 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2012
Rab25 in cancer: a brief update
Shreya Mitra;
Shreya Mitra
1
1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston TX 77054, U.S.A.
1To whom correspondence should be addressed (emailsmitra@mdanderson.org).
Search for other works by this author on:
Kwai W. Cheng;
Kwai W. Cheng
1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston TX 77054, U.S.A.
Search for other works by this author on:
Gordon B. Mills
Gordon B. Mills
1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston TX 77054, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 20 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1404–1408.
Article history
Received:
September 20 2012
Citation
Shreya Mitra, Kwai W. Cheng, Gordon B. Mills; Rab25 in cancer: a brief update. Biochem Soc Trans 1 December 2012; 40 (6): 1404–1408. doi: https://doi.org/10.1042/BST20120249
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.