Comprising over 60 members, Rab proteins constitute the largest branch of the Ras superfamily of low-molecular-mass G-proteins. This protein family have been primarily implicated in various aspects of intracellular membrane trafficking processes. On the basis of distinct subfamily-specific sequence motifs, many Rabs have been grouped into subfamilies. The Rab11 GTPase subfamily comprises three members: Rab11a, Rab11b and Rab25/Rab11c, which, between them, have been demonstrated to bind more than 30 proteins. In the present paper, we review the function of the Rab11 subfamily. We describe their localization and primary functional roles within the cell and their implication, to date, in disease processes. We also summarize the protein machinery currently known to regulate or mediate their functions and the cargo molecules which they have been shown to transport.
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Conference Article|
November 21 2012
Rab11 proteins in health and disease
Eoin E. Kelly;
Eoin E. Kelly
1Molecular Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
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Conor P. Horgan;
Conor P. Horgan
1Molecular Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
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Mary W. McCaffrey
Mary W. McCaffrey
1
1Molecular Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
1To whom correspondence should be addressed (emailm.mccaffrey@ucc.ie).
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Publisher: Portland Press Ltd
Received:
August 09 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2012 The Authors Journal
2012
Biochem Soc Trans (2012) 40 (6): 1360–1367.
Article history
Received:
August 09 2012
Citation
Eoin E. Kelly, Conor P. Horgan, Mary W. McCaffrey; Rab11 proteins in health and disease. Biochem Soc Trans 1 December 2012; 40 (6): 1360–1367. doi: https://doi.org/10.1042/BST20120157
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