Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3–5% of familial and 1–3% of sporadic PD cases with the highest prevalence (up to 40%) in North Africans and Ashkenazi Jews. To date, mutations in LRRK2 are a major genetic risk factor for familial and sporadic PD. Despite the fact that 8 years have passed from the establishment of the first link between PD and dardarin in 2004, the pathophysiological role of LRRK2 in PD onset and progression is far from clearly defined. Also the generation of different LRRK2 transgenic or knockout animals has not provided new hints on the function of LRRK2 in the brain. The present paper reviews recent evidence regarding a potential role of LRRK2 in the regulation of membrane trafficking from vesicle generation to the movement along cytoskeleton and finally to vesicle fusion with cell membrane.
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October 2012
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Conference Article|
September 19 2012
LRRK2 and vesicle trafficking
Giovanna Sanna;
Giovanna Sanna
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy
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Maria Grazia Del Giudice;
Maria Grazia Del Giudice
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy
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Claudia Crosio;
Claudia Crosio
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy
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Ciro Iaccarino
Ciro Iaccarino
1
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy
1To whom correspondence should be addressed (emailciaccarino@uniss.it).
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Publisher: Portland Press Ltd
Received:
May 02 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Article history
Received:
May 02 2012
Citation
Giovanna Sanna, Maria Grazia Del Giudice, Claudia Crosio, Ciro Iaccarino; LRRK2 and vesicle trafficking. Biochem Soc Trans 1 October 2012; 40 (5): 1117–1122. doi: https://doi.org/10.1042/BST20120117
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