The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease–exonuclease–phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4–Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins.
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Conference Article| July 20 2012
Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex
G. Sebastiaan Winkler
G. Sebastiaan Winkler 3
*School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
†Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
3To whom correspondence should be addressed (email@example.com).
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Rachel Doidge, Saloni Mittal, Akhmed Aslam, G. Sebastiaan Winkler; Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex. Biochem Soc Trans 1 August 2012; 40 (4): 896–901. doi: https://doi.org/10.1042/BST20120074
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