Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.
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August 2012
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Conference Article|
July 20 2012
Analysis of urinary microRNAs in chronic kidney disease
Cristina Beltrami;
Cristina Beltrami
*Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K.
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
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Aled Clayton;
Aled Clayton
‡Institute of Cancer and Genetics, Cardiff University School of Medicine, Velindre Cancer Centre, Cardiff CF14 2TL, U.K.
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Aled O. Phillips;
Aled O. Phillips
*Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K.
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
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Donald J. Fraser;
Donald J. Fraser
*Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K.
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
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Timothy Bowen
Timothy Bowen
1
*Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K.
†Cardiff Institute of Tissue Engineering and Repair, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, U.K.
1To whom correspondence should be addressed (emailbowent@cf.ac.uk).
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Publisher: Portland Press Ltd
Received:
March 26 2012
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (4): 875–879.
Article history
Received:
March 26 2012
Citation
Cristina Beltrami, Aled Clayton, Aled O. Phillips, Donald J. Fraser, Timothy Bowen; Analysis of urinary microRNAs in chronic kidney disease. Biochem Soc Trans 1 August 2012; 40 (4): 875–879. doi: https://doi.org/10.1042/BST20120090
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