The most recently identified PLC (phospholipase C) enzymes belong to the PLCη family. Their unique Ca2+-sensitivity and their specific appearance in neurons have attracted great attention since their discovery; however, their physiological role(s) in neurons are still yet to be established. PLCη enzymes are expressed in the neocortex, hippocampus and cerebellum. PLCη2 is also expressed at high levels in pituitary gland, pineal gland and in the retina. Driven by the specific localization of PLCη enzymes in different brain areas, in the present paper, we discuss the roles that they may play in neural processes, including differentiation, memory formation, circadian rhythm regulation, neurotransmitter/hormone release and the pathogenesis of neurodegenerative disorders associated with aberrant Ca2+ signalling, such as Alzheimer's disease.
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February 2012
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Conference Article|
January 19 2012
Putative roles for phospholipase Cη enzymes in neuronal Ca2+ signal modulation
Petra Popovics;
Petra Popovics
1School of Medicine, University of St Andrews, St Andrews KY16 9TF, U.K.
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Alan J. Stewart
Alan J. Stewart
1
1School of Medicine, University of St Andrews, St Andrews KY16 9TF, U.K.
1To whom correspondence should be addressed (email ajs21@st-andrews.ac.uk).
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Publisher: Portland Press Ltd
Received:
June 15 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 282–286.
Article history
Received:
June 15 2011
Citation
Petra Popovics, Alan J. Stewart; Putative roles for phospholipase Cη enzymes in neuronal Ca2+ signal modulation. Biochem Soc Trans 1 February 2012; 40 (1): 282–286. doi: https://doi.org/10.1042/BST20110622
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