DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination. The kinetics of repair of DSBs can differ widely, and recent studies have shown that the higher-order chromatin structure can dramatically affect the pathway utilized, the rate of repair and the genetic factors required for repair. Studies of the repair of DSBs arising within heterochromatic DNA regions have provided insight into the constraints that higher-order chromatin structure poses on repair and the processing that is uniquely required for the repair of such DSBs. In the present paper, we provide an overview of our current understanding of the process of heterochromatic DSB repair in mammalian cells and consider the evolutionary conservation of the processes.
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February 2012
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Conference Article|
January 19 2012
DNA double-strand break repair within heterochromatic regions
Johanne M. Murray;
Johanne M. Murray
1
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, U.K.
1Correspondence may be addressed to either of these authors (email j.m.murray@sussex.ac.uk or p.a.jeggo@sussex.ac.uk).
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Tom Stiff;
Tom Stiff
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, U.K.
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Penny A. Jeggo
Penny A. Jeggo
1
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, U.K.
1Correspondence may be addressed to either of these authors (email j.m.murray@sussex.ac.uk or p.a.jeggo@sussex.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 14 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 173–178.
Article history
Received:
July 14 2011
Citation
Johanne M. Murray, Tom Stiff, Penny A. Jeggo; DNA double-strand break repair within heterochromatic regions. Biochem Soc Trans 1 February 2012; 40 (1): 173–178. doi: https://doi.org/10.1042/BST20110631
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