NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent Ca2+-mobilizing messenger implicated in many Ca2+-dependent cellular processes. It is highly unusual in that it appears to trigger Ca2+ release from acidic organelles such as lysosomes. These signals are often amplified by archetypal Ca2+ channels located in the endoplasmic reticulum. Recent studies have converged on the TPCs (two-pore channels) which localize to the endolysosomal system as the likely primary targets through which NAADP mediates its effects. ‘Chatter’ between TPCs and endoplasmic reticulum Ca2+ channels is disrupted when TPCs are directed away from the endolysosomal system. This suggests that intracellular Ca2+ release channels may be closely apposed, possibly at specific membrane contact sites between acidic organelles and the endoplasmic reticulum.
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February 2012
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Conference Article|
January 19 2012
Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
Sandip Patel;
Sandip Patel
1
*Department of Cell and Developmental Biology, University College London, London WC1E 6BT, U.K.
1To whom correspondence should be addressed (email patel.s@ucl.ac.uk).
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Eugen Brailoiu
Eugen Brailoiu
†Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
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Publisher: Portland Press Ltd
Received:
August 04 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 153–157.
Article history
Received:
August 04 2011
Citation
Sandip Patel, Eugen Brailoiu; Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?. Biochem Soc Trans 1 February 2012; 40 (1): 153–157. doi: https://doi.org/10.1042/BST20110693
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