The nuclear envelope is not only important for the structural integrity of the nucleus, but also involved in a number of cellular functions. It has been shown to be important for maintaining and controlling chromatin organization, sequestering transcription factors, replication, transcription and signalling. The nuclear envelope is thus important for development and differentiation, and some of its components are essential for cell viability. Among the many functions which are emerging for the nuclear envelope is its involvement in protecting the cell against different types of cellular stress. In the present paper, we review key findings which describe the roles of nuclear envelope components in responses to common types of stress conditions.
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December 2011
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Conference Article|
November 21 2011
The nuclear envelope and its involvement in cellular stress responses
Ashraf N. Malhas;
Ashraf N. Malhas
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, U.K.
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David J. Vaux
David J. Vaux
1
1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, U.K.
1To whom correspondence should be addressed (email david.vaux@path.ox.ac.uk).
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Publisher: Portland Press Ltd
Received:
September 08 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Article history
Received:
September 08 2011
Citation
Ashraf N. Malhas, David J. Vaux; The nuclear envelope and its involvement in cellular stress responses. Biochem Soc Trans 1 December 2011; 39 (6): 1795–1798. doi: https://doi.org/10.1042/BST20110719
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