The LINC (linker of nucleoskeleton and cytoskeleton) complex forms a transcisternal bridge across the NE (nuclear envelope) that connects the cytoskeleton with the nuclear interior. This enables some proteins of the NE to communicate with the centrosome and the microtubule cytoskeleton. The position of the centrosome relative to the NE is of vital importance for many cell functions, such as cell migration and division, and centrosomal dislocation is a frequent phenotype in laminopathic disorders. Also in mitosis, a small group of transmembrane NE proteins associate with microtubules when they concentrate in a specific membrane domain associated with the mitotic spindle. The present review discusses structural and functional aspects of microtubule association with NE proteins and how this association may be maintained over the cell cycle.
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Conference Article|
November 21 2011
Microtubule-associated nuclear envelope proteins in interphase and mitosis
Ricardo A. Figueroa;
Ricardo A. Figueroa
*Department of Neurochemistry, Stockholm University, SE-106 91 Stockholm, Sweden
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Santhosh Gudise;
Santhosh Gudise
*Department of Neurochemistry, Stockholm University, SE-106 91 Stockholm, Sweden
†Department of Biosciences and Nutrition, Karolinska Institute (NOVUM), SE-141 89 Huddinge, Sweden
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Einar Hallberg
Einar Hallberg
1
*Department of Neurochemistry, Stockholm University, SE-106 91 Stockholm, Sweden
1To whom correspondence should be addressed (email einar.hallberg@neurochem.su.se).
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Publisher: Portland Press Ltd
Received:
August 08 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1786–1789.
Article history
Received:
August 08 2011
Citation
Ricardo A. Figueroa, Santhosh Gudise, Einar Hallberg; Microtubule-associated nuclear envelope proteins in interphase and mitosis. Biochem Soc Trans 1 December 2011; 39 (6): 1786–1789. doi: https://doi.org/10.1042/BST20110680
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