The nuclear envelope is a complex double membrane system that serves as a dynamic interface between the nuclear and cytoplasmic compartments. Among its many roles is to provide an anchor for gene regulatory proteins on its nucleoplasmic surface and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions come from both inner and outer nuclear membrane NETs and appear to operate through several distinct mechanisms ranging from sequestration of gene-regulatory proteins to activating kinase cascades.
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December 2011
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Conference Article|
November 21 2011
Nuclear envelope influences on cell-cycle progression
Vlastimil Srsen;
Vlastimil Srsen
1Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, U.K.
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Nadia Korfali;
Nadia Korfali
1Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, U.K.
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Eric C. Schirmer
Eric C. Schirmer
1
1Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, U.K.
1To whom correspondence should be addressed (email e.schirmer@ed.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 14 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1742–1746.
Article history
Received:
July 14 2011
Citation
Vlastimil Srsen, Nadia Korfali, Eric C. Schirmer; Nuclear envelope influences on cell-cycle progression. Biochem Soc Trans 1 December 2011; 39 (6): 1742–1746. doi: https://doi.org/10.1042/BST20110656
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