VEGF (vascular endothelial growth factor) is the master regulator of blood vessel growth. However, it displayed substantial limitations when delivered as a single gene to restore blood flow in ischaemic conditions. Indeed, uncontrolled VEGF expression can easily induce aberrant vascular structures, and short-term expression leads to unstable vessels. Targeting the second stage of the angiogenic process, i.e. vascular maturation, is an attractive strategy to induce stable and functional vessels for therapeutic angiogenesis. The present review discusses the limitations of VEGF-based gene therapy, briefly summarizes the current knowledge of the molecular and cellular regulation of vascular maturation, and describes recent pre-clinical evidence on how the maturation stage could be targeted to achieve therapeutic angiogenesis.
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December 2011
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Conference Article|
November 21 2011
Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis
Silvia Reginato;
Silvia Reginato
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
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Roberto Gianni-Barrera;
Roberto Gianni-Barrera
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
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Andrea Banfi
Andrea Banfi
1
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
1To whom correspondence should be addressed (email abanfi@uhbs.ch).
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Publisher: Portland Press Ltd
Received:
July 14 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1654–1658.
Article history
Received:
July 14 2011
Citation
Silvia Reginato, Roberto Gianni-Barrera, Andrea Banfi; Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis. Biochem Soc Trans 1 December 2011; 39 (6): 1654–1658. doi: https://doi.org/10.1042/BST20110652
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