RhoJ is an endothelially expressed member of the Cdc42 (cell division cycle 42) subfamily of small Rho GTPases. It is expressed in both the developing mammalian vasculature and the vascular beds of a number of adult tissues, with its expression regulated by the endothelial transcription factor ERG (ETS-related gene). RhoJ has been shown to regulate endothelial motility, tubulogenesis and lumen formation in vitro, and modulates the vascularization of Matrigel plugs in vivo. Both vascular endothelial growth factor and semaphorin 3E have been found to affect its activation. RhoJ has been shown to be a focal-adhesion-localized Rho GTPase which can modulate focal adhesion number, actomyosin contractility and activity of Cdc42 and Rac1. The present review discusses the biology of RhoJ with a focus on recent reports of its role in endothelial cells and angiogenesis.
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December 2011
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Conference Article|
November 21 2011
The role of RhoJ in endothelial cell biology and angiogenesis
Katarzyna Leszczynska;
Katarzyna Leszczynska
1Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Sukhbir Kaur;
Sukhbir Kaur
1Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Eleanor Wilson;
Eleanor Wilson
1Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Roy Bicknell;
Roy Bicknell
1Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Victoria L. Heath
Victoria L. Heath
1
1Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email v.heath@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 10 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1606–1611.
Article history
Received:
August 10 2011
Citation
Katarzyna Leszczynska, Sukhbir Kaur, Eleanor Wilson, Roy Bicknell, Victoria L. Heath; The role of RhoJ in endothelial cell biology and angiogenesis. Biochem Soc Trans 1 December 2011; 39 (6): 1606–1611. doi: https://doi.org/10.1042/BST20110702
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