The use of non-mammalian model organisms, including yeast Saccharomyces cerevisiae, can provide new insights into eukaryotic PCD (programmed cell death) pathways. In the present paper, we report recent achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA-PCD time course by using both wild-type and mutant yeast cells. Two AA-PCD pathways are described sharing common features, but distinct from one another with respect to the role of ROS and mitochondria, the former in which YCA1 acts upstream of cyt c release and caspase-like activation in a ROS-dependent manner and the latter in which cyt c release does not occur, but caspase-like activity increases, in a ROS-independent manner.
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October 2011
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Conference Article|
September 21 2011
Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways
Nicoletta Guaragnella;
Nicoletta Guaragnella
*CNR, Istituto di Biomembrane e Bioenergetica, Via Amendola 165/A, 70126 Bari, Italy
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Lucia Antonacci;
Lucia Antonacci
†Dipartimento di Scienze per la Salute, Università del Molise, Via De Sanctis, 86100 Campobasso, Italy
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Salvatore Passarella;
Salvatore Passarella
†Dipartimento di Scienze per la Salute, Università del Molise, Via De Sanctis, 86100 Campobasso, Italy
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Ersilia Marra;
Ersilia Marra
*CNR, Istituto di Biomembrane e Bioenergetica, Via Amendola 165/A, 70126 Bari, Italy
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Sergio Giannattasio
Sergio Giannattasio
1
*CNR, Istituto di Biomembrane e Bioenergetica, Via Amendola 165/A, 70126 Bari, Italy
1To whom correspondence should be addressed (email s.giannattasio@ibbe.cnr.it).
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Publisher: Portland Press Ltd
Received:
June 14 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Article history
Received:
June 14 2011
Citation
Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio; Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways. Biochem Soc Trans 1 October 2011; 39 (5): 1538–1543. doi: https://doi.org/10.1042/BST0391538
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