Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation of yeast lifespan, also converge on a common targeted process: autophagy. The molecular mechanisms underlying the regulation of autophagy and aging by these signalling pathways in yeast, with special attention to the TOR pathway, are discussed in the present paper. The question of whether or not autophagy could contribute to yeast cell death occurring during CLS (chronological lifespan) is discussed in the light of our findings obtained after autophagy activation promoted by proteotoxic stress. Autophagy progressively increases in cells expressing the aggregation-prone protein α-synuclein and seems to participate in the early cell death and shortening of CLS under these conditions, highlighting that autophagic activity should be maintained below physiological levels to exert its promising anti-aging effects.
Skip Nav Destination
Article navigation
October 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
September 21 2011
Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?
Belém Sampaio-Marques;
Belém Sampaio-Marques
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, and ICVS/3B's – PT Government Associate Laboratory, Braga/Guimarães, Portugal
Search for other works by this author on:
Carolina Felgueiras;
Carolina Felgueiras
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, and ICVS/3B's – PT Government Associate Laboratory, Braga/Guimarães, Portugal
Search for other works by this author on:
Alexandra Silva;
Alexandra Silva
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, and ICVS/3B's – PT Government Associate Laboratory, Braga/Guimarães, Portugal
Search for other works by this author on:
Fernando Rodrigues;
Fernando Rodrigues
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, and ICVS/3B's – PT Government Associate Laboratory, Braga/Guimarães, Portugal
Search for other works by this author on:
Paula Ludovico
Paula Ludovico
1
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, and ICVS/3B's – PT Government Associate Laboratory, Braga/Guimarães, Portugal
1To whom correspondence should be addressed (email pludovico@ecsaude.uminho.pt).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 05 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1466–1470.
Article history
Received:
June 05 2011
Citation
Belém Sampaio-Marques, Carolina Felgueiras, Alexandra Silva, Fernando Rodrigues, Paula Ludovico; Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?. Biochem Soc Trans 1 October 2011; 39 (5): 1466–1470. doi: https://doi.org/10.1042/BST0391466
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.