WFDC (whey/four-disulfide core)-domain-containing proteins are defined by the possession of one or more 40–50 amino acid domains that include eight conserved cysteine residues linked by four characteristic intramolecular disulfide bonds. Some also contain other structural domains, whereas in many the WFDC-domain is the only domain present. The WFDC-domain is not limited to mammals but is widespread across all lineages. There is increasing evidence to suggest that mammalian WFDC-domain-containing proteins are undergoing rapid molecular evolution and as might be expected they exhibit low levels of sequence similarity coupled with multiple examples of species-specific gene acquisition and gene loss. The characteristic structural domain (that is generally encoded by a single exon) makes these proteins relatively easy to identify in databases. This review will outline the repertoire of such domains within the mouse, but similar principles can be applied to the identification of all proteins within individual species.
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October 2011
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Conference Article|
September 21 2011
Towards defining the complement of mammalian WFDC-domain-containing proteins
Colin D. Bingle
Colin D. Bingle
1
1Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, U.K.
1email c.d.bingle@sheffield.ac.uk
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Publisher: Portland Press Ltd
Received:
June 28 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1393–1397.
Article history
Received:
June 28 2011
Citation
Colin D. Bingle; Towards defining the complement of mammalian WFDC-domain-containing proteins. Biochem Soc Trans 1 October 2011; 39 (5): 1393–1397. doi: https://doi.org/10.1042/BST0391393
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