A comprehensive understanding of ROS (reactive oxygen species)-dependent cellular interaction requires the previously unmet ability to simultaneously monitor the intra- and extra-cellular environments. The present review assesses the potential of novel electrochemical and fluorescent-based nanosensor approaches to address the limitations of existing techniques for ROS analysis. Data generated by these new approaches have already contributed significantly to current understanding of the roles that these species play in various in vitro scenarios. However, integration of these novel approaches has the potential to offer, for the first time, the unparalleled ability to measure simultaneously and in real-time ROS flux in both the intra- and extra-cellular environments.
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October 2011
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Conference Article|
September 21 2011
Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform
Philip Manning;
Philip Manning
1
1Diagnostic and Therapeutic Technologies, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.
1To whom correspondence should be addressed (email philip.manning@ncl.ac.uk).
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Calum J. McNeil
Calum J. McNeil
1Diagnostic and Therapeutic Technologies, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.
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Publisher: Portland Press Ltd
Received:
June 13 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1288–1292.
Article history
Received:
June 13 2011
Citation
Philip Manning, Calum J. McNeil; Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform. Biochem Soc Trans 1 October 2011; 39 (5): 1288–1292. doi: https://doi.org/10.1042/BST0391288
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