During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox changes alter the T-cell proteome in a quantitative and qualitative manner, and post-translational modifications to surface and cytoplasmic proteins by increased reactive species can influence T-cell function. Previously, we have shown that RA (rheumatoid arthritis) T-cells exhibit reduced ROS (reactive oxygen species) production in response to extracellular stimulation compared with age-matched controls, and basal ROS levels [measured as DCF (2′,7′-dichlorofluorescein) fluorescence] are lower in RA T-cells. In contrast, exposing T-cells in vitro to different extracellular redox environments modulates intracellular signalling and enhances cytokine secretion. Together, these data suggest that a complex relationship exists between intra- and extra-cellular redox compartments which contribute to the T-cell phenotype.
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October 2011
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Conference Article|
September 21 2011
Free radicals and redox signalling in T-cells during chronic inflammation and ageing
Helen R. Griffiths;
Helen R. Griffiths
1
*School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.
1To whom correspondence should be addressed (email h.r.griffiths@aston.ac.uk).
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Christopher R. Dunston;
Christopher R. Dunston
*School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.
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Stuart J. Bennett;
Stuart J. Bennett
*School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.
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Melissa M. Grant;
Melissa M. Grant
2
*School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.
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Darren C. Phillips;
Darren C. Phillips
3
*School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.
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George D. Kitas
George D. Kitas
†Russells Hall Hospital, Pensnett Road, Dudley DY1 2HQ, U.K.
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Publisher: Portland Press Ltd
Received:
July 18 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Article history
Received:
July 18 2011
Citation
Helen R. Griffiths, Christopher R. Dunston, Stuart J. Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas; Free radicals and redox signalling in T-cells during chronic inflammation and ageing. Biochem Soc Trans 1 October 2011; 39 (5): 1273–1278. doi: https://doi.org/10.1042/BST0391273
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