In eukaryotes, the final steps in both the regulated and constitutive secretory pathways can be divided into four distinct stages: (i) the ‘approach’ of secretory vesicles/granules to the PM (plasma membrane), (ii) the ‘docking’ of these vesicles/granules at the membrane itself, (iii) the ‘priming’ of the secretory vesicles/granules for the fusion process, and, finally, (iv) the ‘fusion’ of vesicular/granular membranes with the PM to permit content release from the cell. Recent work indicates that non-muscle myosin II and the unconventional myosin motor proteins in classes 1c/1e, Va and VI are specifically involved in these final stages of secretion. In the present review, we examine the roles of these myosins in these stages of the secretory pathway and the implications of their roles for an enhanced understanding of secretion in general.
Skip Nav Destination
Article navigation
October 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
September 21 2011
Myosin motor proteins are involved in the final stages of the secretory pathways
Lisa M. Bond;
Lisa M. Bond
*Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, U.K.
†Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Search for other works by this author on:
Hemma Brandstaetter;
Hemma Brandstaetter
*Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, U.K.
Search for other works by this author on:
James R. Sellers;
James R. Sellers
†Laboratory of Molecular Physiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Search for other works by this author on:
John Kendrick-Jones;
John Kendrick-Jones
‡MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K.
Search for other works by this author on:
Folma Buss
Folma Buss
1
*Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, U.K.
1To whom correspondence should be addressed (email fb1@mole.bio.cam.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 04 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1115–1119.
Article history
Received:
April 04 2011
Citation
Lisa M. Bond, Hemma Brandstaetter, James R. Sellers, John Kendrick-Jones, Folma Buss; Myosin motor proteins are involved in the final stages of the secretory pathways. Biochem Soc Trans 1 October 2011; 39 (5): 1115–1119. doi: https://doi.org/10.1042/BST0391115
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.