PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of sequence similarity coupled with multiple examples of species-specific gene acquisition and gene loss. Vertebrate genomes contain multiple examples of genes that do not meet our original definition of what is required to be a member of the PLUNC family, namely conservation of exon numbers/sizes, overall protein size, genomic location and the presence of a conserved disulfide bond. This suggests that evolutionary forces have continued to act on the structure of this conserved domain in what are likely to be functionally important ways.
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August 2011
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Conference Article|
July 20 2011
Distant cousins: genomic and sequence diversity within the BPI fold-containing (BPIF)/PLUNC protein family
Colin D. Bingle;
Colin D. Bingle
1
*Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield S10 2JF, U.K.
1To whom correspondence should be addressed (email c.d.bingle@sheffield.ac.uk).
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Lynne Bingle;
Lynne Bingle
†Oral and Maxillofacial Pathology, The School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, U.K.
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C. Jeremy Craven
C. Jeremy Craven
‡Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, U.K.
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Publisher: Portland Press Ltd
Received:
May 03 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (4): 961–965.
Article history
Received:
May 03 2011
Citation
Colin D. Bingle, Lynne Bingle, C. Jeremy Craven; Distant cousins: genomic and sequence diversity within the BPI fold-containing (BPIF)/PLUNC protein family. Biochem Soc Trans 1 August 2011; 39 (4): 961–965. doi: https://doi.org/10.1042/BST0390961
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