Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.
Skip Nav Destination
Conference Article| March 22 2011
Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?
Martina Schröder; Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?. Biochem Soc Trans 1 April 2011; 39 (2): 679–683. doi: https://doi.org/10.1042/BST0390679
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article