It is clear that mTORC1 (mammalian target of rapamycin complex 1) is regulated by the presence of ambient amino acid nutrients. However, the mechanism by which amino acids regulate mTORC1 is still open to question, despite extensive efforts. Our recent work has revealed that PR61ϵ, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1. In searching for a physiological process regulated by amino acids, we have demonstrated recently that arginine plays a role in the activation of LPS (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages. PP2A similarly associates with the upstream regulator of MEK in this signalling pathway, TPL-2 (tumour progression locus-2), in response to arginine availability. Thus PP2A is a negative regulator of both MAP4K3 and TPL-2 in both mTORC1 and MEK/ERK signalling pathways.
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April 2011
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Conference Article|
March 22 2011
Signalling by amino acid nutrients
Lijun Yan;
Lijun Yan
*Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G IZ2
†School of Pharmacy, Harbin University of Commerce, 138 Tongda Street, Daoli District, Harbin 150076, P.R. China
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Richard F. Lamb
Richard F. Lamb
1
*Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada, T6G IZ2
1To whom correspondence should be addressed (email rflamb@ualberta.ca).
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Publisher: Portland Press Ltd
Received:
January 12 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (2): 443–445.
Article history
Received:
January 12 2010
Citation
Lijun Yan, Richard F. Lamb; Signalling by amino acid nutrients. Biochem Soc Trans 1 April 2011; 39 (2): 443–445. doi: https://doi.org/10.1042/BST0390443
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